Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation

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Title: Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation Running title: Skeletal muscle phenotype of OEG-transplanted paraplegic rats Key words: Skeletal muscle phenotype, myosin subunit isoforms, muscle paralysis

Paralyzed skeletal muscle of rats with spinal cord injury (SCI) undergoes atrophy and a switch in gene expression pattern which leads to faster, more fatigable phenotypes. Olfactory ensheathing glia (OEG) transplants have been reported to promote axonal regeneration and to restore sensory-motor function in animals with SCI. We hypothesized that OEG-transplants could attenuate skeletal muscle ph...

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Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection.

Spinal Wistar Hannover rats injected with olfactory ensheathing glia (OEG) have been shown to recover some bipedal stepping and climbing abilities. Given the intrinsic ability of the spinal cord to regain stepping with pharmacological agents or epidural stimulation after a complete mid-thoracic transection, we asked if functional recovery after OEG injections is due to changes in the caudal stu...

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Noradrenergic innervation of the rat spinal cord caudal to a complete spinal cord transection: effects of olfactory ensheathing glia.

Transplantation of olfactory bulb-derived olfactory ensheathing glia (OEG) combined with step training improves hindlimb locomotion in adult rats with a complete spinal cord transection. Spinal cord injury studies use the presence of noradrenergic (NA) axons caudal to the injury site as evidence of axonal regeneration and we previously found more NA axons just caudal to the transection in OEG- ...

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Chronic hypobaric hypoxia increases isolated rat fast-twitch and slow-twitch limb muscle force and fatigue.

Chronic hypoxia alters respiratory muscle force and fatigue, effects that could be attributed to hypoxia and/or increased activation due to hyperventilation. We hypothesized that chronic hypoxia is associated with phenotypic change in non-respiratory muscles and therefore we tested the hypothesis that chronic hypobaric hypoxia increases limb muscle force and fatigue. Adult male Wistar rats were...

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Long-term effects of spinal cord transection on fast and slow rat skeletal muscle. I. Contractile properties.

Contractile properties of rat soleus and extensor digitorum longus muscles were studied 1 year after complete thoracic spinal cord transection (spinal cord level T9). Force-generating capacity and contraction speed were unchanged in the extensor digitorum longus 1 year after transection. However, the rate of contraction and relaxation increased in the soleus as reflected by a decrease in time-t...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 2008

ISSN: 0022-3751

DOI: 10.1113/jphysiol.2007.149120